Uridine-5'-diphosphate disodium salt_product_DataBase

Bioactivity	Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
Invitro	Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2]. Uridine-5'-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2]. Uridine-5'-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2]. Uridine-5'-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2]. Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2]. Uridine-5'-diphosphate disodium salt is a competitive antagonist at the human P2Y14 receptor (pEC50=7.28) but not rat P2Y14 receptor[1]. UDP-glucose (UDPG; HY-N7032) is a potent P2Y14 agonist[3][4]. RT-PCR[2] Cell Line:
Name	Uridine-5'-diphosphate disodium salt
CAS	27821-45-0
Formula	C9H12N2Na2O12P2
Molar Mass	448.12
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

PeptideDB

Uridine-5'-diphosphate disodium salt

CAS: 27821-45-0 F: C9H12N2Na2O12P2 W: 448.12