| Bioactivity | UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties[1]. |
| Target | Kd: 79 µM (UHM domain) |
| Invitro | UHMCP1 (25-400 μM) reduces the binding of purified U2AF65 to SF3b155 by 75%, exhibiting a simple, non-cooperative binding mode with Kd around 30 μM for U2AF65[1].UHMCP1 (0-200 μM; 24 h) exhibits a certain effect on cell viability of HEK293[1]. Cell Viability Assay[1] Cell Line: |
| Name | UHMCP1 |
| CAS | 2103079-87-2 |
| Formula | C19H27N3 |
| Molar Mass | 297.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kobayashi A, et al. Identification of a small molecule splicing inhibitor targeting UHM domains. FEBS J. 2022 Feb;289(3):682-698. |