| Bioactivity | Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1]. |
| Invitro | Tyrosol (1.6 mM) significantly increases the cell viability of cultured astrocytes exposed to oxygen glucose deprivation (OGD)[1]. Tyrosol (1.6 mM) attenuates the released TNF-α and IL-6 level from astrocyte via regulating Janus N-terminal kinase (JNK) [1]. The reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of STAT3 signaling pathway since Tyrosol (1.6 mM) attenuates the expression level of GFAP (glial fibrillary acidic protein) and the phosphorylation of STAT3[1]. Tyrosol prevents the degradation of IκBα and the increase of IκBα phosphorylation in astrocytes exposed to OGD, which leads to the suppression of NF-κB function during ischemia[1]. |
| Name | Tyrosol |
| CAS | 501-94-0 |
| Formula | C8H10O2 |
| Molar Mass | 138.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |