Tyr-α-CGRP (human) (TFA)_product_DataBase

Bioactivity	Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC50 values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC50 values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC50 value of 1.9 nM[1][2].
Sequence	Tyr-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (disulfide bridge: Cys3-Cys8)
Shortening	YACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (disulfide bridge: Cys3-Cys8)
Formula	C172H276N52O51S2.xC2HF3O2
Molar Mass	3952.48 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Poyner D R, et al. Pharmacological characterization of a receptor for calcitonin gene‐related peptide on rat, L6 myocytes[J]. British journal of pharmacology, 1992, 105(2): 441-447. [2]. Dennis T, et al. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity[J]. Journal of Pharmacology and Experimental Therapeutics, 1989, 251(2): 718-725.

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