Tubulin polymerization-IN-28_product_DataBase

Bioactivity	Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research[1].
Invitro	Tubulin polymerization-IN-28 (compound-4) (9-381 nM，48 hours)has a significant inhibitory effect on tumor cells[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) inhibits microtubule assembly with anti-tumor activity[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) causes G2/M phase arrest in cells[1]. Tubulin polymerization-IN-28 (compound-4) (10 nM，24 hours) leads to significant cell apoptosis[1]. Cell Proliferation Assaysup>[1] Cell Line:
In Vivo	Tubulin polymerization-IN-28 (compound-4) (intraperitoneal injection, every day, 17days) exhibits good anti-cancer activity in HepG2 xenograft-bearing BALB/c mice model in vivo[1]. Animal Model:
Name	Tubulin polymerization-IN-28
CAS	2481404-89-9
Formula	C37H46N2O9
Molar Mass	662.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chong Zhang,et al. NQO1-selective activated prodrugs of combretastatin A-4: Synthesis and biological evaluation. Bioorg Chem. 2020 Oct;103:104200.

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