| Bioactivity | Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity[1]. |
| Invitro | Triclopyr (3 mM; 48 hours) treatment exhibits cytotoxicity against N2a cells[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | Pharmacokinetic AnalysisTriclopyr exhibits moderate half-lives (dog 25 h and monkey 6.3 h) due to plasma clearance (18 mL/h/kg, 26 mL/h/kg respectively) following oral gavage (3 male beagle dogs ;0.5 mg/kg, 5 mg/kg and 20 mg/kg) and intravenous administration (1 male rhesus monkey; 30 mg/kg) [2]. Animal Model: |
| Name | Triclopyr |
| CAS | 55335-06-3 |
| Formula | C7H4Cl3NO3 |
| Molar Mass | 256.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tejaswini P Reddy, et al. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health. 2011 Jan;8(1):203-21. [2]. C Timchalk, et al. Pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat, monkey, and human. Toxicol Appl Pharmacol. 1997 Jun;144(2):268-78. |