| Bioactivity | Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2]. | |||||||||
| Invitro | Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3]. | |||||||||
| Name | Triacsin C | |||||||||
| CAS | 76896-80-5 | |||||||||
| Formula | C11H17N3O | |||||||||
| Molar Mass | 207.27 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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