| Bioactivity | Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist. | ||||||||||||
| Target | NK-1 | ||||||||||||
| Invitro | Results reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal)[1]. | ||||||||||||
| In Vivo | Autoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands[1]. | ||||||||||||
| Name | Tradipitant | ||||||||||||
| CAS | 622370-35-8 | ||||||||||||
| Formula | C28H16ClF6N5O | ||||||||||||
| Molar Mass | 587.90 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gackenheimer SL, et al. In vitro and ex vivo autoradiography of the NK-1 antagonist [3H]-LY686017 in Guinea pig brain. Neuropeptides. 2011 Apr;45(2):157-64. |