| Bioactivity | Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3]. |
| Invitro | Tiron (10 mM) 保护中国仓鼠 V79 细胞免受 H2O2 诱导的细胞毒性[1]。Tiron (0-20 mM) 保护超螺旋 DNA 免受金属介导的超氧化物依赖性链断裂[1]。Tiron (50 nM-200 nM, 48 h) 抑制 HG 诱导的新生大鼠心肌细胞凋亡[3]。Tiron (50 nM-200 nM, 48 h) 降低新生大鼠心肌细胞内的骨桥蛋白[3]。Tiron (0.2 mM，2 小时) 抑制 UVB 诱导的 HDF 中 MMP-1 和 MMP-3 的上调[4]。Tiron (0.7 mM，48 小时) 增加 S 期和 G2/M 期 PT4 细胞的百分比[5]。 Cell Cycle Analysis[5] Cell Line: |
| Name | Tiron |
| CAS | 149-45-1 |
| Formula | C6H4Na2O8S2 |
| Molar Mass | 314.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |