| Bioactivity | Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2]. | ||||||||||||
| Invitro | Thiamphenicol shows a significant post-antibiotic effect (PAE) (0.33 to 2.9h) on all pathogens studied (S. pneumoniae, S. aureus and Escherichia coli) and a powerful bactericidal effect against β-lactamase-positive and -negative H. influenzae. Thiamphenicol MICs for the microorganisms analyzed are: 32 mg/L (S. aureus and E. coli), 2 mg/L (S. pneumoniae) and 0.25 mg/L (H. influenzae). Thiamphenicol shows a good in vitro activity against difficult-to-treat multiply resistant pathogens[1]. | ||||||||||||
| Name | Thiamphenicol | ||||||||||||
| CAS | 15318-45-3 | ||||||||||||
| Formula | C12H15Cl2NO5S | ||||||||||||
| Molar Mass | 356.22 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Thiamphenicol
CAS: 15318-45-3 F: C12H15Cl2NO5S W: 356.22
Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibio
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