| Bioactivity | Tetracycline-d6-1 is deuterated labeled 2-Isobutyl-3-methoxypyrazine (HY-W017141). 2-Isobutyl-3-methoxypyrazine is an aroma constituent in grapes andwines, green pepper and asparagus[1]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Tetracycline 显示出对 V. vulnlflcus 菌株 B3547 的敏感性，MIC 值为 0.5 g/mL[3]。 Tetracycline 抑制L-淀粉样蛋白聚集体的形成并分解预先形成的原纤维[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tetracycline-d6-1 相关抗体: |
| In Vivo | Tetracycline (3 mg/kg；每 12 小时腹腔注射一次直至存活) 使菌血症小鼠存活[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C22H18D6N2O8 |
| Molar Mass | 450.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chopra I, et al. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60. [3]. Bowdre JH, et al. Antibiotic efficacy against Vibrio vulnificus in the mouse: superiority of tetracycline. J Pharmacol Exp Ther. 1983 Jun;225(3):595-8. [4]. Forloni G, et al. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 2001 Jan 5;487(3):404-7. |