| Bioactivity | Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic[1][2]. |
| Invitro | Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1][2]. |
| Name | Tetracaine hydrochloride |
| CAS | 136-47-0 |
| Formula | C15H25ClN2O2 |
| Molar Mass | 300.82 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
| Reference | [1]. http://en.wikipedia.org/wiki/Tetracaine [2]. http://www.ncbi.nlm.nih.gov/pubmed/9147318 |