| Bioactivity | Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research[1][2][3][4][5]. | ||||||
| Invitro | Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells[1]. Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway[1]. Cell Proliferation Assay[1] Cell Line: | ||||||
| Name | Terlipressin acetate | ||||||
| CAS | 1884420-36-3 | ||||||
| Sequence | Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9) | ||||||
| Shortening | GGGCYFQNCPKG-NH2 (Disulfide bridge: Cys4-Cys9) | ||||||
| Formula | C56H82N16O19S2 | ||||||
| Molar Mass | 1347.48 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Stored under nitrogen, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
Terlipressin acetate
CAS: 1884420-36-3 F: C56H82N16O19S2 W: 1347.48
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selec
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