| Bioactivity | TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-ADV agent with neuroprotective effects. TZ4M exhibits AChE inhibition in human plasma. TZ4M improves memory and cognitive impairment in adult rats in a scopolamine (HY-N0296)-induced Alzheimer-type model[1]. |
| Target | AChE |
| In Vivo | 大鼠模型，TZ4M (2、3 mg/kg；腹腔注射；每天 1 次，共 8 天) 抑制东莨菪碱 (3 mg/kg；腹腔注射) 诱导的海马神经元损伤和海马神经元和皮质蛋白凋亡，增加海马和皮质 DG 区和 CA1 神经元中 mAChR M1 的数量[1]。 TZ4M 经 CBligand-BBB 预测为 BBB 阳性，这是 AChE 抑制所需要的[1]。 |
| Name | TZ4M |
| Formula | C19H15NO4S |
| Molar Mass | 353.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Taheri M, et al. Neuroprotective Effect of Thiazolidine-2,4-dione Derivatives on Memory Deficits and Neuropathological Symptoms of Dementia on a Scopolamine-Induced Alzheimer's Model in Adult Male Wistar Rats. ACS Chem Neurosci. 2023 Sep 6;14(17):3156-3172.. . |