| Bioactivity | TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2]. |
| Invitro | TXA6101 has antibacterial activity against MRSA with the MIC value of 0.125 μg/mL while TXA707 with the MIC value of 1 μg/mL[2].TXY6129 inhibits the polymerization of Escherichia coli FtsZ in a concentration-dependent manner and induces morphological changes in Escherichia coli and Klebsiella pneumoniae[3]. |
| Name | TXA6101 |
| CAS | 1459695-66-9 |
| Formula | C18H10BrF5N2O3 |
| Molar Mass | 477.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69. [2]. Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. [3]. Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo). 2022 Jul;75(7):385-395. |
TXA6101
CAS: 1459695-66-9 F: C18H10BrF5N2O3 W: 477.18
TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial divi
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