| Bioactivity | TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)[1]. |
| Invitro | TP-TRFS (10 μM) exhibits weak fluorescence (Φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (Φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h[1]. |
| In Vivo | TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function[1]. |
| Name | TP-TRFS |
| Formula | C16H15NO3S2 |
| Molar Mass | 333.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb). 2020 Nov 12;56(90):14075-14078. |