| Bioactivity | TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1]. | ||||||||||||
| Target | EC50: 520 nM (M1R) | ||||||||||||
| In Vivo | TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747-induced cognitive deficits in rats at 0.3 mg/kg[1]. TAK-071 also induce diarrhea at 10 mg/kg in rats[1].Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats[1]. | ||||||||||||
| Name | TAK-071 | ||||||||||||
| CAS | 1820812-16-5 | ||||||||||||
| Formula | C24H24FN3O3 | ||||||||||||
| Molar Mass | 421.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Sako Y, et al. TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8. |
TAK-071
CAS: 1820812-16-5 F: C24H24FN3O3 W: 421.46
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator.
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