| Bioactivity | T7 peptide is an endothelial cell-specific inhibitor. T7 peptide interacts with αVβ3 integrin to inhibit the FAK, PI3-kinase, PKB/Akt, and mTOR/ signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis[1]. |
| Sequence | Thr-Met-Pro-Phe-Leu-Phe-Cys-Asn-Val-Asn-Asp-Val-Cys-Asn-Phe-Ala-Ser-Arg-Asn-Asp-Tyr-Ser-Tyr-Trp-Leu (Disulfide bridge: Cys7-Cys13) |
| Shortening | TMPFLFCNVNDVCNFASRNDYSYWL (Disulfide bridge: Cys7-Cys13) |
| Formula | C137H189N33O39S3 |
| Molar Mass | 3018.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maeshima Y, et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science. 2002 Jan 4;295(5552):140-3. |