| Bioactivity | T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile[1]. |
| In Vivo | T14-A24 (10 mg/kg，口服)可改善 Aβ 1-42 诱导的认知障碍，显着预防 Aβ 1-42 毒性对小鼠的影响[1]。 |
| Name | T14-A24 |
| Formula | C24H24N6O3S |
| Molar Mass | 476.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang K, et al. Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2237213. |