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Bioactivity T14-A24 is an orally active, reversible, competitive, and selective AChE inhibitor (Ki=22 nM, IC50=6 nM). T14-A24 has benign BBB penetration, remarkable neuroprotective effect, and safe toxicological profile[1].
In Vivo T14-A24 (10 mg/kg,口服)可改善 Aβ 1-42 诱导的认知障碍,显着预防 Aβ 1-42 毒性对小鼠的影响[1]。
Name T14-A24
Formula C24H24N6O3S
Molar Mass 476.55
Transport Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Tang K, et al. Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2237213.

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