| Bioactivity | Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM[1]. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity[2]. |
| Invitro | Swinholide A, first isolated from the Okinawan marine sponge Theonella swinhoei, dimerizes actin[1].Swinholide A, isolated from the marien sponge Theonella swinhoei, is highly cytotoxic to a variety of cancer cell lines[2].Swinholide A disrupts the actin cytoskeleton of cells grown in culture, sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers with a binding stoichiometry of one swinholide A molecule per actin dimer, and rapidly severs F-actin in vitro with high cooperativity[2]. Cell Viability Assay[2] Cell Line: |
| Name | Swinholide A |
| CAS | 95927-67-6 |
| Formula | C78H132O20 |
| Molar Mass | 1389.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Swinholide A
CAS: 95927-67-6 F: C78H132O20 W: 1389.87
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM. Swinholide A is a microf
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