| Bioactivity | Streptozotocin (Streptozocin) is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA. |
| Target | DNA alkylator |
| Invitro | Streptozotocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). ALX appeares not to be toxic for the studied cell lines with estimated IC50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Streptozotocinn is more toxic, especially for the human myeloid leukemia cell line, HL60. The IC50 values of Streptozotocin are 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells, respectively. Results also show that the murine leukemic cells are more resistant to Streptozotocin and ALX cytotoxicity than human leukemic cells[2]. |
| In Vivo | Streptozotocin (STZ)-injected mice show tendency to have lower body weight than that observed in animals injected with ALX. Streptozotocin -injected mice have significantly fewer splenocytes (22.2±3.2×106; n=10) compared to mice injected with ALX (60.7±4.3×106; n=15; p=0.01)[2]. |
| Name | Streptozotocin |
| CAS | 18883-66-4 |
| Formula | C8H15N3O7 |
| Molar Mass | 265.22 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
| Reference | [1]. Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90 [2]. Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8 [3]. Acer S, et al. Oxidative stress of crystalline lens in rat menopausal model. Arq Bras Oftalmol. 2016 Jul-Aug;79(4):222-5. |
Streptozotocin
CAS: 18883-66-4 F: C8H15N3O7 W: 265.22
Streptozotocin (Streptozocin) is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kid
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