Stilbamidine dihydrochloride_product_DataBase

Bioactivity	Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.
Invitro	高亲和力 pentamidine 转运蛋白 (HAPT1) 被 Propamidine 抑制，但对 Stilbamidine dihydrochloride 仅显示低亲和力。相反，腺苷敏感的 pentamidine 转运蛋白 (ASPT1) 会被二盐酸二苯巴脒和 Propamidine 强烈抑制。在不同浓度的腺苷 (IC50=1.2 μM) 或 Melarsen oxide (IC50=0.7 μM) 存在下测定 [3H]pentamidine 摄取=0.7 μM)，以及存在 250 μM 腺苷和增加浓度的次黄嘌呤、Propamidine (IC50=6.1 μM) 和 Stilbamidine dihydrochloride (IC50=110 μM)[1]。两种二脒化合物，Stilbamidine dihydrochloride 和 Pentamidine 用于治疗多发性骨髓瘤，这种疾病经常发生血清球蛋白含量增加[2]。
Name	Stilbamidine dihydrochloride
CAS	6935-63-3
Formula	C16H18Cl2N4
Molar Mass	337.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. De Koning HP. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol Pharmacol. 2001 Mar;59(3):586-92. [2]. BREWER AE.et al. Multiple myeloma treated with stilbamidine and pentamidine. Br Med J. 1948 Dec 4;2(4587):978-82.

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