| Bioactivity | Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1]. |
| Target | IC50: angiotensin converting enzyme |
| In Vivo | Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.[2] Animal Model: |
| Name | Spirapril hydrochloride |
| CAS | 94841-17-5 |
| Formula | C22H31ClN2O5S2 |
| Molar Mass | 503.07 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Spirapril. Drugbank. [2]. B Maul, et al. Alcohol consumption is controlled by angiotensin II. FASEB J |
Spirapril hydrochloride
CAS: 94841-17-5 F: C22H31ClN2O5S2 W: 503.07
Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive acti
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