Sp-5,6-DCl-cBIMPS_product_DataBase

Bioactivity	Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].
Invitro	Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 以剂量和时间依赖性方式刺激离体胰岛释放胰岛素[2]。Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 增加葡萄糖 (8.5 mM) 刺激的胰岛素释放[2]。SSp-5,6-DCl-cBIMPS (100 µM; 20 min) 抑制野生型小鼠血小板中 U46619 诱导的 Rho 激活，并抑制 U46619 诱导的人血小板中 Gq 和 G12/G13 激活[3 ]。 Western Blot Analysis[3] Cell Line:
Name	Sp-5,6-DCl-cBIMPS
CAS	120912-54-1
Formula	C12H11Cl2N2O5PS
Molar Mass	397.17
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7. [2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22. [3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.

PeptideDB

Sp-5,6-DCl-cBIMPS

CAS: 120912-54-1 F: C12H11Cl2N2O5PS W: 397.17