Sodium 2-mercaptoethanesulfonate_product_DataBase

Bioactivity	Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].
Invitro	Mesna (1-1000 μM) reduces H2O2, HOCl and OH• concentrations in a dose-dependent manner, with an IC50 of 32, 21, and 305 μM, respectively in cell-free experiments[3].
In Vivo	Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury[1].Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats[2]. Animal Model:
Name	Sodium 2-mercaptoethanesulfonate
CAS	19767-45-4
Formula	C2H5NaO3S2
Molar Mass	164.18
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149. [2]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85. [3]. Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17(3):76-80.

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