| Bioactivity | Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4]. | |||||||||
| Invitro | Silymarin (0-120 µg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 µg/ml silymarin, 71.5% at 40 µg/ml, 59.8% at 60 µg/ml, 44.5% at 80 µg/ml, 35.3% at 100 µg/ml and 33.9% at 120 µg/ml[1].Silymarin (40-80 µg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 µg/ml and 21.7% at 80 µg/ml,respectively[1]. Cell Viability Assay[2] Cell Line: | |||||||||
| Name | Silymarin | |||||||||
| CAS | 65666-07-1 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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