| Bioactivity | Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3]. |
| Invitro | Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL)[2]. |
| In Vivo | Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice[3].Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice[3].Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression[3]. |
| Name | Sevelamer hydrochloride |
| CAS | 152751-57-0 |
| Formula | (C3H7N.C3H5ClO)x.xHCl |
| Molar Mass | 186.08 (monomer) |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Sevelamer, From Wikipedia [2]. Bennis Y, et al. The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Toxins (Basel). 2019 May 17;11(5):279. [3]. Susan C Schiavi, et al. Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol. 2012 Oct;23(10):1691-700. |
Sevelamer hydrochloride
CAS: 152751-57-0 F: (C3H7N.C3H5ClO)x.xHCl W: 186.08 (monomer)
Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chro
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