| Bioactivity | Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells[1][2][3][4]. |
| Invitro | Sertaconazole nitrate (0.03-40 µg/mL; 24 h) inhibits 150 strains of yeasts which includes six Candida species with arithmetic mean MIC of 0.77 µg/mL[1].Sertaconazole nitrate (1 µg/mL; 5, 10, 30, 60 min) activates p38 MAP kinase in a time-dependent manner[2].Sertaconazole nitrate (1, 2 µg/mL; 6, 8, or 24 h) increases a twofold release of PGE2 via COX-2 in keratinocytes, which is dependent on p38 activation[2].Sertaconazole nitrate (10, 20, 30, 40 µM; 24 h) induces strong mitotic arrest by depolymerizing interphase and spindle microtubules, thereby inducing chromosome aggregation defects and causing anti-proliferation effect[3].Sertaconazole nitrate (20, 40 µM; 24 h) induces apoptosis through p53 pathway in HeLa cells[3].Sertaconazole nitrate (20, 30 µM; 24, 48, and 72 h) inhibits the migration of HeLa cells in a concentration-dependent manner[3].Sertaconazole nitrate (15, 30 µM; 24 h) induces autophagy in A549, H460 cells[4]. Cell Viability Assay[1] Cell Line: |
| Name | Sertaconazole nitrate |
| CAS | 99592-39-9 |
| Formula | C20H16Cl3N3O4S |
| Molar Mass | 500.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Sertaconazole nitrate
CAS: 99592-39-9 F: C20H16Cl3N3O4S W: 500.78
Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via act
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