| Bioactivity | Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects[2]. |
| CAS | 1383743-23-4 |
| Sequence | Pro-Glu-Asp-Gln-Glu-Leu-Glu-Ser-Leu-Ser-Ala-Ile-Glu-Ala-Glu-Leu-Glu-Lys-Val-Ala-His-Gln-Leu-Gln-Ala-Leu |
| Shortening | PEDQELESLSAIEAELEKVAHQLQAL |
| Formula | C125H204N32O46 |
| Molar Mass | 2891.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Koshimizu H, et al. Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells. Mol Endocrinol. 2011 May;25(5):732-44. [2]. Loh YP, et al. Chromogranin A and derived peptides in health and disease. J Mol Neurosci. 2012 Oct;48(2):347-56. |
Serpinin
CAS: 1383743-23-4 F: C125H204N32O46 W: 2891.14
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the
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This product is for research use only, not for human use. We do not sell to patients.