| Bioactivity | Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2]. | ||||||||||||
| Target | IC50: 123 nM (SirT1) | ||||||||||||
| Invitro | Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells[1]. | ||||||||||||
| In Vivo | Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD)[1]. | ||||||||||||
| Name | Selisistat | ||||||||||||
| CAS | 49843-98-3 | ||||||||||||
| Formula | C13H13ClN2O | ||||||||||||
| Molar Mass | 248.71 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Smith MR, et al. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet. 2014;23(11):2995-3007. [2]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 [published correction appears in J Med Chem. 2007 Mar 8;50(5):1086]. J Med Chem. 2005;48(25):8045-8054. |
Selisistat
CAS: 49843-98-3 F: C13H13ClN2O W: 248.71
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM f
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.