Scyliorhinin II_product_DataBase

Bioactivity	Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
Target	Ki: 2.5 nM (Neurokinin-3 receptor)
Invitro	Scyliorhinin II is a neurokinin-3 selective tachykinin receptor, with a Ki of 2.5 nM for neurokinin-3 (NK-3) receptor in rat cerebral cortex. Scyliorhinin II has little effect on NK-1 and NK-2 receptors, with Ki (NK-1 receptor)/Ki (NK-3 receptor) and Ki (NK-2 receptor)/Ki (NK-3 receptor) of 176 and 200[1].
In Vivo	Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2].
Name	Scyliorhinin II
CAS	112748-19-3
Sequence	Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2
Shortening	SPSNSKCPDGPDCFVGLM-NH2
Formula	C77H119N21O26S3
Molar Mass	1851.09
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. [2]. Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91.

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