| Bioactivity | Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1]. |
| Invitro | Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7 µM to 6.5 µM[1].Scoulerine (2.5-20 µM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells[1].Scoulerine (2.5-20 µM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis[1].Scoulerine induces G2 or M cell cycle arrest[1].Scoulerine (2.5-5 µM; 24 hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells[1].Scoulerine (2.5-5 µM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner[1].Scoulerine (5-10 µM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cells[1] Cell Proliferation Assay[1] Cell Line: |
| Name | Scoulerine |
| CAS | 6451-73-6 |
| Formula | C19H21NO4 |
| Molar Mass | 327.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |