| Bioactivity | Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities[1][2][3]. | ||||||||||||
| Invitro | Schisandrol B (Gomisin-A; 1-10 μM; 2 days) treatment decreases the aging related inflammatory molecules, such as, COX-2, IL1β, and TNF-α. Schisandrol B attenuates the activity of senescence-associated β-galactosidase[2].Schisandrol B (Gomisin-A; 1-10 μM; 2 days) inhibits reactive oxygen species production even in the stress-induced premature senescence (SIPS)-human diploid fibroblast (HDF) cells[2].Schisandrol B (Gomisin-A; 1-10 μM) inhibits the MAPK pathway and the translocation of NF-κB to the nucleus[2].Schisandrol B (Gomisin-A; 1-10 μM) promotes the autophagy and mitochondrial biogenesis factors through the translocation of Nrf-2, and inhibits aging progression in the SIPS-HDF cells[2].Schisandrol B (0-80 μM) dramatically alters APAP metabolic activation by inhibiting the activities of CYP2E1 and CYP3A11[1]. Western Blot Analysis[2] Cell Line: | ||||||||||||
| Name | Schisandrol B | ||||||||||||
| CAS | 58546-54-6 | ||||||||||||
| Formula | C23H28O7 | ||||||||||||
| Molar Mass | 416.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Schisandrol B
CAS: 58546-54-6 F: C23H28O7 W: 416.46
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisand
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