| Bioactivity | Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats[1][2][3]. | ||||||||||||
| Invitro | Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells[1].Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages[1].Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively[3].Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance[4]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Schisandrin | ||||||||||||
| CAS | 7432-28-2 | ||||||||||||
| Formula | C24H32O7 | ||||||||||||
| Molar Mass | 432.51 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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