| Bioactivity | Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication. | ||||||
| Invitro | Salvianolic acid B (SA-B) 1 and 10 micromol/L decrease the cell active TGF-beta1 secretion by 63.3 % and 15.6 % of the control, down-regulat pro-collgen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B 1 and 10 micromol/L also inhibit MAPK activity by 1 to 2 fold respectively.[3]The degradation of Salvianolic acid B is temperature dependent. It was stable at 4ºC for 30 h in aqueous solution. However, decomposition of Salvianolic acid B aqueous solution occurres automatically at 25ºC, and is enhanced at 37, 65 and 100ºC. On the other hand, Salvianolic acid B is also stable at 4, 25 and 37ºC for 30 h in TPA (total phenolic acids).[4]Salvianolic acid B is stable for 30 h in buffered phosphate aqueous solutions at pH 1.5, 3.0 and 5.0. With an increase of pH from the neutral, the stability of Sal B decreased.[4] | ||||||
| Name | Salvianolic acid B | ||||||
| CAS | 121521-90-2 | ||||||
| Formula | C36H30O16 | ||||||
| Molar Mass | 718.61 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage |
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Salvianolic acid B
CAS: 121521-90-2 F: C36H30O16 W: 718.61
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the manage
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