| Bioactivity | Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
| Invitro | Saccharopine 积累导致线粒体损伤和功能丧失，这是由 C. elegans 中 α-氨基己二酸半醛合酶 (AASS-1) 的糖苷脱氢酶 (SDH) 突变引起的[1]。 |
| Name | Saccharopine hydrochloride |
| Formula | C11H21ClN2O6 |
| Molar Mass | 312.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Saccharopine hydrochloride
CAS: F: C11H21ClN2O6 W: 312.75
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-
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