| Bioactivity | Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties[1]. | ||||||||||||
| Invitro | In vitro, saccharin (0.5, 2.5, 5 mM) inhibits bacterial growth in a species-dependent manner[1]. | ||||||||||||
| In Vivo | In vivo, saccharin (oral; 5 mg/kg; twice a day) intake reduces fecal bacterial load and alters microbiome composition, while the intestinal barrier is not obviously affected in male C57BL/6JRj wild type (wt) mice[1]. | ||||||||||||
| Name | Saccharin | ||||||||||||
| CAS | 81-07-2 | ||||||||||||
| Formula | C7H5NO3S | ||||||||||||
| Molar Mass | 183.18 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sünderhauf A, et al. Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. Nutrients. 2020 Apr 17;12(4). pii: E1122. |