| Bioactivity | STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1]. | ||||||||||||
| Invitro | STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)[1].STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells[1].STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC50 value of 16.77 μM while 2'3'-cGAMP acts with an EC50 value of 9.212 μM[1]. | ||||||||||||
| Name | STING agonist-16 | ||||||||||||
| CAS | 652142-94-4 | ||||||||||||
| Formula | C19H11Cl2N5O | ||||||||||||
| Molar Mass | 396.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hui Hou, et al. Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening. Bioorg Chem. 2020 Jul;100:103958. |
STING agonist-16
CAS: 652142-94-4 F: C19H11Cl2N5O W: 396.23
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as
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