| Bioactivity | STING-IN-5 is a potent STING inhibitor, inhibiting LPS-induced NO synthesis in macrophages with an IC50 value of 1.15 μM. STING-IN-5 inhibits the inflammatory response. STING-IN-5 can be used to research anti-inflammatory diseases and sepsis[1]. |
| Invitro | STING-IN-5 (化合物30) (40 μM; 24 h) 对 RAW264.7 细胞活力影响较小[1]。STING-IN-5 (2.5 和 5 μM; 2 h) 抑制 LPS 刺激的 RAW264.7 细胞产生 NO，在 2.5 μM 和 5 μM 下的抑制率分别为 69.28 ± 2.36% 和 78.66 ± 2.73%，IC50 为 1.15 ± 0.15 μM[1]。STING-IN-5 (0.5-2 μM; 2 h) 抑制 STING，以及 TBK1/IRF3/NF-κB 激活[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | STING-IN-5 (1.25-5 mg/kg；灌胃；每日 1 次，连续 3 天) 对脓毒症小鼠急性肝损伤有明显保护作用[1]。Pharmacokinetic Parameters of STING-IN-5 in male Sprague-Dawley rats[1]. Tmax (h) |
| Name | STING-IN-5 |
| Formula | C47H67NO9S2 |
| Molar Mass | 854.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Long J, et al. Discovery of fusidic acid derivatives as novel STING inhibitors for treatment of sepsis. Eur J Med Chem. 2022 Dec 15;244:114814. |