SPC-180002_product_DataBase

Bioactivity	SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].
Invitro	SPC-180002（0-5 μM，24 小时）通过 p21 积累抑制细胞周期进程，从而导致随后的细胞衰老[1]。SPC-180002 不会诱导细胞凋亡和自噬[1]。 0 --> SPC-180002 相关抗体:
In Vivo	SPC-180002（1-5mg/kg，每周两次，腹腔注射）可抑制多种癌细胞的生长，并阻碍 MCF7 肿瘤异种移植小鼠中的肿瘤生长[1]。 Animal Model:
Name	SPC-180002
CAS	2170274-53-8
Formula	C18H23NO4
Molar Mass	317.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.

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