| Bioactivity | SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2]. | ||||||||||||
| Target | IC50: 255 nM (SF-1) | ||||||||||||
| Invitro | SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2]. | ||||||||||||
| Name | SID7970631 | ||||||||||||
| CAS | 868224-75-3 | ||||||||||||
| Formula | C24H24N2O7 | ||||||||||||
| Molar Mass | 452.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784. [2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23. |
SID7970631
CAS: 868224-75-3 F: C24H24N2O7 W: 452.46
SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID797063
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