| Bioactivity | SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1]. | ||||||||||||
| Target | Separase | ||||||||||||
| Invitro | SIC5-6 (30 μM, 100 μM) 增加 HeLa 细胞中 Caspase-1 活性和 Rad21 裂解。(Rad21：含有与荧光染料 Rh110 (HY-D0817) 结合的 Separase 裂解位点)[1] | ||||||||||||
| Name | SIC5-6 | ||||||||||||
| CAS | 2410846-16-9 | ||||||||||||
| Formula | C27H24IN3O2S | ||||||||||||
| Molar Mass | 581.47 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14(10):2155-2159. |
SIC5-6
CAS: 2410846-16-9 F: C27H24IN3O2S W: 581.47
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mi
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