SH-BC-893_product_DataBase

Bioactivity	SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity[1][2].
Invitro	SH-BC-893 通过下调细胞表面营养转运蛋白和阻断溶酶体运输事件来饿死癌细胞[1]。SH-BC-893（5 μM；3 小时）通过破坏细胞内运输来防止神经酰胺诱导的线粒体网络断裂[2]。SH-BC-893（8.935 nM；3 小时）防止神经酰胺诱导的线粒体功能障碍[2]。 Western Blot Analysis[1] Cell Line:
In Vivo	SH-BC-893（口服；120 mg/kg；单次）强烈而敏锐地阻断神经酰胺诱导的线粒体功能障碍，纠正饮食诱导的肥胖及其代谢后遗症[1]。 Animal Model:
Name	SH-BC-893
CAS	1841409-92-4
Formula	C19H32ClNO
Molar Mass	325.92
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kubiniok, Peter et al. Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs. Molecular & cellular proteomics : MCP vol. 18,3 (2019): 408-422. [2]. Jayashankar, Vaishali et al. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO molecular medicine vol. 13,8 (2021): e13086.

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