| Bioactivity | SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2]. | ||||||||||||
| Target | enkephalinase | ||||||||||||
| Invitro | SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3]. | ||||||||||||
| In Vivo | SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1]. | ||||||||||||
| Name | SCH 32615 | ||||||||||||
| CAS | 83861-02-3 | ||||||||||||
| Formula | C21H24N2O5 | ||||||||||||
| Molar Mass | 384.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. [2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. [3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38. |