SB-269970 hydrochloride_product_DataBase

Bioactivity	SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors[1][2].
In Vivo	SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity[2]. Animal Model:
Name	SB-269970 hydrochloride
CAS	261901-57-9
Formula	C18H29ClN2O3S
Molar Mass	388.95
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. http://www.ncbi.nlm.nih.gov/pubmed/10821781 [2]. Roberts C, et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132(7):1574-80. [3]. Monti JM, et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res. 2008 Aug 22;191(2):184-9.

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