SARS-CoV-2 3CLpro-IN-5_product_DataBase

Bioactivity	SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CLpro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19)[1].
Target	IC50: 3.8 nM (3CLpro).EC50 for SARS-CoV-2 strains: 13.8 nM (α), 7.57 nM (δ), 9.01 nM (Om BA.1) and 17.1 nM (Om BA.2) . EC50: 59.3 nM (SARS-CoV in 293TAT cells); 4.72 nM (MERS-CoV in 293TDPP4 cells); 1.67 nM (HCoV-OC43 in 293TAT cells).
Invitro	SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM[1].SARS-CoV-2 3CLpro-IN-5 has antiviral activity in 293TAT cells againsts various SARS-CoV-2 strains α, δ, Om BA.1 and Om BA.2 with EC50 values of 13.8 nM, 7.57 nM, 9.01 nM and 17.1 nM, respectively[1].SARS-CoV-2 3CLpro-IN-5 has antiviral activity against various coronaviruses SARS-CoV (293TAT cells), MERS-CoV (293TDPP4 cells) and HCoV-OC43 (293TAT cells) with EC50 values of 59.3 nM, 4.72 nM and 1.67 nM, respectively[1].
In Vivo	SARS-CoV-2 3CLpro-IN-5 (oral, i.v.; 10, 100 mg/kg) has strong antiviral activity and favorable pharmacokinetic properties[1]. Animal Model:
Name	SARS-CoV-2 3CLpro-IN-5
Formula	C22H26ClF2N5O4
Molar Mass	497.92
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yuya Hirose, et al. Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease. J Med Chem

PeptideDB

SARS-CoV-2 3CLpro-IN-5

CAS: F: C22H26ClF2N5O4 W: 497.92