SAMe-1,4-Butanedisulfonate_product_DataBase

Bioactivity	SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders[1][2][3][4].
In Vivo	SAMe-1,4-Butanedisulfonate (30 和 60 mg/kg/天，肌肉注射) 增加实验性骨关节炎兔损伤软骨的厚度和细胞密度[2]。SAMe-1,4-Butanedisulfonate (60 和 100 mg/kg/天，肌肉注射) 保护大鼠免受 d-半乳糖胺诱导的肝损伤[3]。SAMe-1,4-Butanedisulfonate (10-200 mg/kg，腹腔注射) 对接受强迫游泳试验 (FST) 和悬尾试验 (TST) 的小鼠表现出抗抑郁样作用[4]。 Animal Model:
Name	SAMe-1,4-Butanedisulfonate
CAS	101020-79-5
Formula	C15H23N6O5S.C4H10O6S2.1/2C4H8O6S2
Molar Mass	726.82
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76(5):1172S-6S. [2]. Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187(2):74-8. Spanish. [3]. Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27(10):1431-3. [4]. Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442.

PeptideDB

SAMe-1,4-Butanedisulfonate

CAS: 101020-79-5 F: C15H23N6O5S.C4H10O6S2.1/2C4H8O6S2 W: 726.82