| Bioactivity | Radicicol is an inhibitor of Hsp90 with an IC50 value P. falciparum topoisomerase VIB[2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM[3]. | ||||||||||||
| Invitro | Radicicol (1 μM or 100 μM) inhibits the activities of Hsp90 and Topo VI by blocking ATP binding[1].Radicicol (100 μM; 10 min) binds to ATP-binding site in the C-terminal domain of PDK3 and prevents maturation of Hsp90 clients[1].Radicicol (0.25-18 μM; 48 h) inhibits P. falciparum 3D7 growth with an IC50 value of 8.563 μM, and (8 μM; 50 h) delays the schizont-to-ring transition[2].Radicicol (1.5 μM; 40 h) suppresses mitochondrial DNA replication without affecting nuclear and apicoplast genomes[2]. Radicicol (0.001-5 μM; 72 h) induces myoblast differentiation with the myoblast toxicity concentration of 0.1 μM[5]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Radicicol | ||||||||||||
| CAS | 12772-57-5 | ||||||||||||
| Formula | C18H17ClO6 | ||||||||||||
| Molar Mass | 364.78 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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