| Bioactivity | Ru265 trichloride is a cell-permeable mitochondrial calcium uniporter (MCU) inhibitor and can be used for the research of ischemic stroke[1]. | |||||||||
| Target | Mitochondrial calcium uniporter | |||||||||
| Invitro | Ru265 (1-10 μM; 30 min or 24 h) produces a concentration-dependent protection of cortical neurons against oxygen–glucose deprivation (OGD)[1].Ru265 (10 μM; 30 min) blocks calpain activation in cortical neurons subjected to OGD[1].Ru265 (50 μM; 24 or 48 h) preserves mitochondrial respiration and glycolysis in OGD-treated cortical neurons[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RU265 trichloride 相关抗体: Cell Viability Assay[1] Cell Line: | |||||||||
| In Vivo | Ru265 (3-30 mg/kg; i.p.; once) produces dose-dependent increases in seizure-like behaviours in mice[1].Ru265 (1-10 mg/kg; i.p.; once) reduces hypoxic/ischemic-induced sensorimotor deficits and brain injury in mice[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | |||||||||
| CAS | 27056-01-5 | |||||||||
| Formula | Cl5H24N9Ru2 | |||||||||
| Molar Mass | 529.66 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Novorolsky RJ, et al. The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury. J Cereb Blood Flow Metab. 2020 Jun;40(6):1172-1181. |
RU265 trichloride
CAS: 27056-01-5 F: Cl5H24N9Ru2 W: 529.66
Ru265 trichloride is a cell-permeable mitochondrial calcium uniporter (MCU) inhibitor and can be used for the research o
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