RU 24969 succinate_product_DataBase

Bioactivity

RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].

Target

Ki: 0.38 nM (5-HT1B), 2.5 nM (5-HT1A)

Invitro

RU 24969 succinate (30 nM-1 μM) 抑制 K+ 诱发的氚外排，在 1 μM 浓度下 pD2 为 7.45[1]。

In Vivo

RU 24969 succinate (1 和 3 mg/kg；皮下注射，1 次) 增强可卡因诱导产生的作用[2]。RU 24969 succinate (0.03-3.0 mg/kg；皮下注射，1 次) 剂量依赖性地减少水剥夺大鼠的水消耗[4]。 Animal Model:

Name

RU 24969 succinate

CAS

107008-28-6

Formula

C18H22N2O5

Molar Mass

346.38

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Middlemiss DN. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J Pharm Pharmacol. 1985 Jun;37(6):434-7. [2]. Parsons LH, et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. [3]. Peroutka SJ. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. J Neurochem. 1986 Aug;47(2):529-40. [4]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4.

PeptideDB

RU 24969 succinate

CAS: 107008-28-6 F: C18H22N2O5 W: 346.38